99mTc-glutathione: role of reducing agent on renal retention.
نویسندگان
چکیده
منابع مشابه
Evaluation of ِdiagnostic role of 99mTc-Tetrofosmin scintigraphy in cold thyroid nodules [Persian]
Introduction: Various radiopharmaceuticals, including 67Ga, 201Tl, and 99mTc-sestamibi have been used to differentiate benign from malignant thyroid nodules. 99mTc-Tetrofosmin, a lipophilic cationic radiotracer, and 99mTc-sestamibi have also been reported to accumulate in thyroid tumors. In this study, we evaluated the role of 99mTc-Tetrofosmin in the differentiation of malignant from ben...
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Radionuclidic techniques may provide assessment of glomerular filtration rate (GFR) effective renal plasma flow (ERPF) or individual renal function. Several agents were available for determination of these parameters such as ¹³¹I-OIH (O-iodohippurate) and different derivatives of DADS (Diamidodisulfur). OIH has the disadvantage of imparting a relatively high absorbed radiation dose to the...
متن کاملAssessment of antioxidative ability in brain: technetium-99m-meso-HMPAO as an imaging agent for glutathione localization.
UNLABELLED To visualize the regional localization of glutathione (GSH) in the brain, the relationship between the concentrations of tissue GSH and uptake of [99mTc]meso-hexamethyl propyleneamine oxime ([99mTc] meso-HMPAO) or [99mTc]d,l-hexamethyl propyleneamine oxime ([99mTc]d,l-HMPAO) was studied in mice. METHODS The uptake of [99mTc]meso-HMPAO in the mouse brain was decreased to 35% of cont...
متن کاملTechnetium-99m complex of N-(2-pyridylmethyl)iminodiacetic acid as a new renal radiopharmaceutical.
A tetradentate chelating agent constituting of an iminodiacetic acid group and a nitrogen atom of pyridine, N-(2-pyridylmethyl)iminodiacetic acid (PMIDA), was coordinated with 99mTc and evaluated as a renal functional agent. The complex of PMIDA with 99mTc was prepared by using a stannous chloride solution as a reducing agent. The chelating efficiency was analyzed by thin layer chromatography a...
متن کاملAntioxidant properties of repaglinide and its protections against cyclosporine A-induced renal tubular injury
Objective(s): Repaglinide (RG) is an antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus. It has a good safety and efficacy profile in diabetic patients with complications in renal impairment and is an appropriate treatment choice, even for individuals with more severe degrees of renal malfunctions. The aim of the present study was to examine the protective...
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عنوان ژورنال:
- International journal of nuclear medicine and biology
دوره 5 2-3 شماره
صفحات -
تاریخ انتشار 1978